USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: ITA6_HUMAN USC-OGP 2-DE database:  ITA6_HUMAN ITA6_HUMAN General information about the entry View entry in simple text format Entry name ITA6_HUMAN Primary accession number P23229 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Integrin alpha-6; AltName: Full=CD49 antigen-like family member F; AltName: Full=VLA-6; AltName: CD_antigen=CD49f; Contains: RecName: Full=Integrin alpha-6 heavy chain; Contains: RecName: Full=Integrin alpha-6 light chain; Contains: RecName: Full=Processed integrin alpha-6; Short=Alpha6p; Flags: Precursor;. Gene name Name=ITGA6 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0262: pI=5.03; Mw=156901 Cross-references UniProtKB/Swiss-Prot P23229; ITA6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ITA6_HUMAN Primary accession number P23229 Secondary accession number(s) B2RMU9 B4DG69 B4DKB8 C4AM96 G5E9H1 Q08443 Q0MRC7 Q14646 Q16508 Q53RX7 Q59HB7 Q86VL6 Q9UCT1 Q9UN03 Sequence was last modified on  June 26, 2013 (version 5) Annotations were last modified on  March 15, 2017 (version 188) Name and origin of the protein Description RecName: Full=Integrin alpha-6; AltName: Full=CD49 antigen-like family member F; AltName: Full=VLA-6; AltName: CD_antigen=CD49f; Contains: RecName: Full=Integrin alpha-6 heavy chain; Contains: RecName: Full=Integrin alpha-6 light chain; Contains: RecName: Full=Processed integrin alpha-6; Short=Alpha6p; Flags: Precursor; Gene name Name=ITGA6 Encoded on Name=ITGA6 Keywords Alternative splicing; Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Epidermolysis bullosa; Glycoprotein; Integrin; Lipoprotein; Membrane; Metal-binding; Palmitate; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X53586; CAA37655.1; -; mRNA EMBL AF166343; AAD48469.1; -; Genomic_DNA EMBL AF166335; AAD48469.1; JOINED; Genomic_DNA EMBL AF166336; AAD48469.1; JOINED; Genomic_DNA EMBL AF166337; AAD48469.1; JOINED; Genomic_DNA EMBL AF166338; AAD48469.1; JOINED; Genomic_DNA EMBL AF166339; AAD48469.1; JOINED; Genomic_DNA EMBL AF166340; AAD48469.1; JOINED; Genomic_DNA EMBL AF166341; AAD48469.1; JOINED; Genomic_DNA EMBL AF166342; AAD48469.1; JOINED; Genomic_DNA EMBL AK294436; BAG57680.1; ALT_INIT; mRNA EMBL AK296496; BAG59130.1; -; mRNA EMBL AC078883; AAX93133.1; -; Genomic_DNA EMBL CH471058; EAX11176.1; -; Genomic_DNA EMBL CH471058; EAX11177.1; -; Genomic_DNA EMBL BC050585; AAH50585.1; -; mRNA EMBL BC136455; AAI36456.1; -; mRNA EMBL BC136456; AAI36457.1; -; mRNA EMBL X59512; CAA42099.1; -; mRNA EMBL S66213; AAB20355.1; -; mRNA EMBL S66196; AAB20354.1; -; mRNA EMBL S52135; AAB24829.1; -; Genomic_DNA EMBL L40385; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AB208842; BAD92079.1; -; mRNA EMBL DQ858220; ABH11650.1; -; mRNA CCDS CCDS2249.1; -. [P23229-2]; . CCDS CCDS46451.1; -. [P23229-3]; . CCDS CCDS82534.1; -. [P23229-7]; . PIR A41543; A41543; . PIR B36429; B36429; . RefSeq NP_000201.2; NM_000210.3. [P23229-2]; . RefSeq NP_001073286.1; NM_001079818.2. [P23229-3]; . RefSeq NP_001303235.1; NM_001316306.1. [P23229-7]; . UniGene Hs.133397; -; . ProteinModelPortal P23229; -; . BioGrid 109864; 32; . IntAct P23229; 6; . MINT MINT-5002506; -; . STRING 9606.ENSP00000386896; -; . ChEMBL CHEMBL3716; -; . TCDB 8.A.54.1.2; the integrin (integrin) family; . iPTMnet P23229; -; . PhosphoSitePlus P23229; -; . SwissPalm P23229; -; . BioMuta ITGA6; -; . DMDM 519668687; -; . OGP P23229; -; . EPD P23229; -; . MaxQB P23229; -; . PaxDb P23229; -; . PeptideAtlas P23229; -; . PRIDE P23229; -; . Ensembl ENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]; . Ensembl ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]; . Ensembl ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]; . Ensembl ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]; . Ensembl ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]; . GeneID 3655; -; . KEGG hsa:3655; -; . UCSC uc002uho.2; human. [P23229-1]; . CTD 3655; -; . DisGeNET 3655; -; . GeneCards ITGA6; -; . GeneReviews ITGA6; -; . H-InvDB HIX0023932; -; . HGNC HGNC:6142; ITGA6; . HPA CAB009009; -; . HPA HPA012696; -; . HPA HPA027582; -; . MalaCards ITGA6; -; . MIM 147556; gene; . MIM 226730; phenotype; . neXtProt NX_P23229; -; . OpenTargets ENSG00000091409; -; . Orphanet 79403; Junctional epidermolysis bullosa - pyloric atresia; . PharmGKB PA29942; -; . eggNOG ENOG410IPBB; Eukaryota; . eggNOG ENOG410XVGZ; LUCA; . GeneTree ENSGT00760000118782; -; . HOVERGEN HBG108011; -; . InParanoid P23229; -; . KO K06485; -; . OMA INQQGRW; -; . OrthoDB EOG091G012D; -; . PhylomeDB P23229; -; . TreeFam TF105391; -; . Reactome R-HSA-2022090; Assembly of collagen fibrils and other multimeric structures; . Reactome R-HSA-210991; Basigin interactions; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-3000157; Laminin interactions; . Reactome R-HSA-3000170; Syndecan interactions; . Reactome R-HSA-446107; Type I hemidesmosome assembly; . SignaLink P23229; -; . SIGNOR P23229; -; . ChiTaRS ITGA6; human; . GeneWiki ITGA6; -; . GenomeRNAi 3655; -; . PMAP-CutDB Q53RX7; -; . PRO PR:P23229; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000091409; -; . CleanEx HS_ITGA6; -; . ExpressionAtlas P23229; baseline and differential; . Genevisible P23229; HS; . GO GO:0009925; C:basal plasma membrane; IEA:Ensembl; . GO GO:0005604; C:basement membrane; IEA:Ensembl; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005913; C:cell-cell adherens junction; IEA:Ensembl; . GO GO:0009897; C:external side of plasma membrane; IEA:Ensembl; . GO GO:0030175; C:filopodium; IEA:Ensembl; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030056; C:hemidesmosome; IEA:Ensembl; . GO GO:0034676; C:integrin alpha6-beta4 complex; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:BHF-UCL; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0097186; P:amelogenesis; IMP:UniProtKB; . GO GO:0050873; P:brown fat cell differentiation; IEA:Ensembl; . GO GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl; . GO GO:0007160; P:cell-matrix adhesion; IEA:Ensembl; . GO GO:0031589; P:cell-substrate adhesion; IMP:UniProtKB; . GO GO:0007044; P:cell-substrate junction assembly; TAS:ProtInc; . GO GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl; . GO GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl; . GO GO:0048565; P:digestive tract development; IMP:UniProtKB; . GO GO:0010668; P:ectodermal cell differentiation; IEP:UniProtKB; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0046847; P:filopodium assembly; IEA:Ensembl; . GO GO:0031581; P:hemidesmosome assembly; TAS:Reactome; . GO GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0035878; P:nail development; IMP:UniProtKB; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL; . GO GO:0043065; P:positive regulation of apoptotic process; IGI:MGI; . GO GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL; . GO GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl; . GO GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl; . GO GO:0043547; P:positive regulation of GTPase activity; IMP:UniProtKB; . GO GO:0042327; P:positive regulation of phosphorylation; IMP:BHF-UCL; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:0072001; P:renal system development; IMP:UniProtKB; . GO GO:0016337; P:single organismal cell-cell adhesion; IEA:Ensembl; . GO GO:0043588; P:skin development; IMP:UniProtKB; . InterPro IPR013517; FG-GAP; . InterPro IPR013519; Int_alpha_beta-p; . InterPro IPR000413; Integrin_alpha; . InterPro IPR013649; Integrin_alpha-2; . InterPro IPR018184; Integrin_alpha_C_CS; . InterPro IPR032695; Integrin_dom; . Pfam PF01839; FG-GAP; 2; . Pfam PF08441; Integrin_alpha2; 1; . PRINTS PR01185; INTEGRINA; . SMART SM00191; Int_alpha; 5; . SUPFAM SSF69179; SSF69179; 3; . PROSITE PS51470; FG_GAP; 7; . PROSITE PS00242; INTEGRIN_ALPHA; 1; .

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